Drug interactions
Fluconazole + Triazolam
Severity: Major
Fluconazole and Triazolam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole increases triazolam exposure, leading to greater and longer sedation and psychomotor impairment. The effect is clinically meaningful.
What this interaction means in plain words
Fluconazole and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Fluconazole inhibits CYP3A4, reducing triazolam first-pass and systemic metabolism.
What to do
Use a reduced triazolam dose or choose a benzodiazepine not dependent on CYP3A4 such as lorazepam. Monitor for excessive sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Triazolam?
MediHelp rates the interaction as major. Fluconazole and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole increases triazolam exposure, leading to greater and longer sedation and psychomotor impairment. The effect is clinically meaningful.
How serious is the interaction between Fluconazole and Triazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced triazolam dose or choose a benzodiazepine not dependent on CYP3A4 such as lorazepam. Monitor for excessive sedation and respiratory depression.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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