Drug interactions
Fluconazole + Tropisetron
Severity: Moderate
Fluconazole and Tropisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QT interval, and fluconazole may also raise tropisetron levels via CYP3A4 inhibition. This adds to arrhythmia risk in predisposed patients.
What this interaction means in plain words
Fluconazole and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation, with possible CYP3A4 inhibition increasing tropisetron exposure.
What to do
Monitor ECG in patients with cardiac risk factors and correct potassium and magnesium. Consider another antiemetic if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Tropisetron?
MediHelp rates the interaction as moderate. Fluconazole and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may prolong the QT interval, and fluconazole may also raise tropisetron levels via CYP3A4 inhibition. This adds to arrhythmia risk in predisposed patients.
How serious is the interaction between Fluconazole and Tropisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors and correct potassium and magnesium. Consider another antiemetic if risk is high.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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