Drug interactions
Fluconazole + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Fluconazole and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can raise exposure to both components of the inhaled combination, mainly through CYP3A4 inhibition. Higher vilanterol exposure may amplify beta-agonist cardiovascular effects such as tachycardia, palpitations and QT prolongation, and higher fluticasone furoate exposure may increase systemic corticosteroid effects. Fluconazole itself can prolong the QT interval.
What this interaction means in plain words
Fluconazole and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluconazole inhibits CYP3A4, reducing clearance of vilanterol and fluticasone furoate, with possible additive QT prolongation.
What to do
Monitor heart rate, ECG and potassium in patients with cardiac risk factors, and watch for systemic corticosteroid effects during prolonged use. Consider an alternative antifungal or bronchodilator if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Fluconazole and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can raise exposure to both components of the inhaled combination, mainly through CYP3A4 inhibition. Higher vilanterol exposure may amplify beta-agonist cardiovascular effects such as tachycardia, palpitations and QT prolongation, and higher fluticasone furoate exposure may increase systemic corticosteroid effects. Fluconazole itself can prolong the QT interval.
How serious is the interaction between Fluconazole and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium in patients with cardiac risk factors, and watch for systemic corticosteroid effects during prolonged use. Consider an alternative antifungal or bronchodilator if QT risk is high.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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