Drug interactions
Fluconazole + Zanubrutinib
Severity: Moderate
Fluconazole and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole raises zanubrutinib exposure, which may increase adverse effects such as bleeding, infection and cytopenias.
What this interaction means in plain words
Fluconazole and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Zanubrutinib belongs to Oncology.
Why it happens
Fluconazole inhibits CYP3A4 metabolism of zanubrutinib.
What to do
Reduce zanubrutinib to 80 mg twice daily during moderate CYP3A inhibitor use and monitor blood counts and bleeding. Return to the usual dose after fluconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Fluconazole with Zanubrutinib?
MediHelp rates the interaction as moderate. Fluconazole and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole raises zanubrutinib exposure, which may increase adverse effects such as bleeding, infection and cytopenias.
How serious is the interaction between Fluconazole and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce zanubrutinib to 80 mg twice daily during moderate CYP3A inhibitor use and monitor blood counts and bleeding. Return to the usual dose after fluconazole is stopped.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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