Drug interactions
Fluconazole + Zolpidem
Severity: Minor
Fluconazole and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may modestly increase zolpidem exposure, leading to greater sedation and next-day impairment. Zolpidem is metabolised by several CYP enzymes, so the effect is generally small.
What this interaction means in plain words
Fluconazole and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Zolpidem belongs to Central Nervous System.
Why it happens
Fluconazole inhibits CYP3A4, one of several pathways metabolising zolpidem.
What to do
No routine dose adjustment is needed; counsel the patient on additive sedation and consider a lower zolpidem dose if excessive drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Zolpidem
Frequently asked questions
Can I take Fluconazole with Zolpidem?
MediHelp rates the interaction as minor. Fluconazole and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole may modestly increase zolpidem exposure, leading to greater sedation and next-day impairment. Zolpidem is metabolised by several CYP enzymes, so the effect is generally small.
How serious is the interaction between Fluconazole and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed; counsel the patient on additive sedation and consider a lower zolpidem dose if excessive drowsiness occurs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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