Drug interactions
Flucytosine + Ganciclovir
Severity: Moderate
Flucytosine and Ganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can suppress bone marrow, causing neutropenia, anemia and thrombocytopenia, so combined use may increase hematologic toxicity. Both are renally cleared, so renal impairment compounds the risk.
What this interaction means in plain words
Flucytosine and Ganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flucytosine belongs to Anti Fungals; Ganciclovir belongs to Anti Virals.
Why it happens
Additive myelosuppressive toxicity.
What to do
Monitor complete blood counts frequently and renal function, adjust doses to creatinine clearance, and consider flucytosine levels if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ganciclovir
Other interactions of Flucytosine
- Amphotericin b + Flucytosine Major
- Deferiprone + Flucytosine Major
- Flucytosine + Ifosfamide Major
- Flucytosine + Lomustine Major
- Fluconazole + Flucytosine Moderate
- Flucytosine + Hydroxycarbamide Moderate
Frequently asked questions
Can I take Flucytosine with Ganciclovir?
MediHelp rates the interaction as moderate. Flucytosine and Ganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can suppress bone marrow, causing neutropenia, anemia and thrombocytopenia, so combined use may increase hematologic toxicity. Both are renally cleared, so renal impairment compounds the risk.
How serious is the interaction between Flucytosine and Ganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and renal function, adjust doses to creatinine clearance, and consider flucytosine levels if available.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
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