Drug interactions
Deferiprone + Flucytosine
Severity: Major
Deferiprone and Flucytosine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flucytosine can cause leukopenia, thrombocytopenia and marrow depression, especially with renal impairment. Combined with deferiprone, neutropenia and agranulocytosis risk may increase.
What this interaction means in plain words
Deferiprone and Flucytosine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Flucytosine belongs to Anti Fungals.
Why it happens
Additive bone marrow suppression.
What to do
Avoid concurrent use where possible. If needed, monitor absolute neutrophil count and flucytosine levels and renal function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Other interactions of Flucytosine
- Amphotericin b + Flucytosine Major
- Flucytosine + Ifosfamide Major
- Flucytosine + Lomustine Major
- Fluconazole + Flucytosine Moderate
- Flucytosine + Ganciclovir Moderate
- Flucytosine + Hydroxycarbamide Moderate
Frequently asked questions
Can I take Deferiprone with Flucytosine?
MediHelp rates the interaction as major. Deferiprone and Flucytosine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Flucytosine can cause leukopenia, thrombocytopenia and marrow depression, especially with renal impairment. Combined with deferiprone, neutropenia and agranulocytosis risk may increase.
How serious is the interaction between Deferiprone and Flucytosine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If needed, monitor absolute neutrophil count and flucytosine levels and renal function closely.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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