Drug interactions
Fluconazole + Flucytosine
Severity: Moderate
Fluconazole and Flucytosine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole and flucytosine are used together, notably for cryptococcal meningitis, where the combination shows additive or synergistic antifungal activity. Fluconazole can reduce renal function in some patients, which may raise flucytosine levels and increase risk of bone marrow and liver toxicity.
What this interaction means in plain words
Fluconazole and Flucytosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Flucytosine belongs to Anti Fungals.
Why it happens
Complementary antifungal mechanisms (ergosterol synthesis inhibition plus fungal nucleic acid synthesis disruption); flucytosine accumulates if renal clearance falls.
What to do
Monitor renal function, complete blood counts and liver enzymes during combined therapy, and adjust flucytosine dose to renal function, ideally with flucytosine level monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Flucytosine
- Amphotericin b + Flucytosine Major
- Deferiprone + Flucytosine Major
- Flucytosine + Ifosfamide Major
- Flucytosine + Lomustine Major
- Flucytosine + Ganciclovir Moderate
- Flucytosine + Hydroxycarbamide Moderate
Frequently asked questions
Can I take Fluconazole with Flucytosine?
MediHelp rates the interaction as moderate. Fluconazole and Flucytosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole and flucytosine are used together, notably for cryptococcal meningitis, where the combination shows additive or synergistic antifungal activity. Fluconazole can reduce renal function in some patients, which may raise flucytosine levels and increase risk of bone marrow and liver toxicity.
How serious is the interaction between Fluconazole and Flucytosine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, complete blood counts and liver enzymes during combined therapy, and adjust flucytosine dose to renal function, ideally with flucytosine level monitoring.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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