Drug interactions
Flucytosine + Hydroxycarbamide
Severity: Moderate
Flucytosine and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flucytosine can cause bone marrow suppression, particularly with high drug levels or renal impairment. Adding hydroxyurea increases the risk of leukopenia and thrombocytopenia.
What this interaction means in plain words
Flucytosine and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flucytosine belongs to Anti Fungals; Hydroxycarbamide belongs to Oncology.
Why it happens
Additive myelosuppressive effects.
What to do
Monitor blood counts and renal function closely, and flucytosine levels where available. Adjust doses or stop one agent if marked cytopenias appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Other interactions of Flucytosine
- Amphotericin b + Flucytosine Major
- Deferiprone + Flucytosine Major
- Flucytosine + Ifosfamide Major
- Flucytosine + Lomustine Major
- Fluconazole + Flucytosine Moderate
- Flucytosine + Ganciclovir Moderate
Frequently asked questions
Can I take Flucytosine with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Flucytosine and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flucytosine can cause bone marrow suppression, particularly with high drug levels or renal impairment. Adding hydroxyurea increases the risk of leukopenia and thrombocytopenia.
How serious is the interaction between Flucytosine and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function closely, and flucytosine levels where available. Adjust doses or stop one agent if marked cytopenias appear.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine, Stavudine, Adenovirus types 4 and 7 live. The full list is on the Hydroxycarbamide page.
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