Drug interactions
Flucytosine + Tenofovir disoproxil
Severity: Moderate
Flucytosine and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flucytosine is eliminated renally and can cause bone marrow suppression, with toxicity rising when kidney function declines. Combined with tenofovir, which can cause renal tubular injury, flucytosine accumulation becomes more likely.
What this interaction means in plain words
Flucytosine and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential additive nephrotoxicity, with impaired renal elimination of flucytosine and tenofovir.
What to do
Monitor renal function and blood counts closely and adjust flucytosine dose to creatinine clearance. Measure flucytosine levels where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flucytosine
- Amphotericin b + Flucytosine Major
- Deferiprone + Flucytosine Major
- Flucytosine + Ifosfamide Major
- Flucytosine + Lomustine Major
- Fluconazole + Flucytosine Moderate
- Flucytosine + Ganciclovir Moderate
Frequently asked questions
Can I take Flucytosine with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Flucytosine and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flucytosine is eliminated renally and can cause bone marrow suppression, with toxicity rising when kidney function declines. Combined with tenofovir, which can cause renal tubular injury, flucytosine accumulation becomes more likely.
How serious is the interaction between Flucytosine and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts closely and adjust flucytosine dose to creatinine clearance. Measure flucytosine levels where available.
What other medicines interact with Flucytosine?
MediHelp also lists interactions of Flucytosine with, for example, Amphotericin b, Deferiprone, Ifosfamide. The full list is on the Flucytosine page.
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