Drug interactions
Fludrocortisone + Fosaprepitant
Severity: Minor
Fludrocortisone and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, the active form of fosaprepitant, is a moderate CYP3A4 inhibitor and can modestly raise levels of CYP3A4-metabolized corticosteroids. The effect is usually small with single-dose fosaprepitant but may increase fludrocortisone effects.
What this interaction means in plain words
Fludrocortisone and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant moderately inhibits CYP3A4, reducing corticosteroid metabolism.
What to do
No routine dose change is needed; monitor blood pressure and potassium if fludrocortisone is used with repeated fosaprepitant dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fludrocortisone
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fludrocortisone with Fosaprepitant?
MediHelp rates the interaction as minor. Fludrocortisone and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant, the active form of fosaprepitant, is a moderate CYP3A4 inhibitor and can modestly raise levels of CYP3A4-metabolized corticosteroids. The effect is usually small with single-dose fosaprepitant but may increase fludrocortisone effects.
How serious is the interaction between Fludrocortisone and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor blood pressure and potassium if fludrocortisone is used with repeated fosaprepitant dosing.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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