Drug interactions
Fludrocortisone + Furosemide
Severity: Moderate
Fludrocortisone and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents increase urinary potassium loss, so concurrent use can cause significant hypokalemia. Fludrocortisone has strong mineralocorticoid activity, making the effect more pronounced and raising arrhythmia risk.
What this interaction means in plain words
Fludrocortisone and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Furosemide belongs to Cardiovascular.
Why it happens
Additive renal potassium excretion from loop diuretic action and mineralocorticoid receptor stimulation.
What to do
Monitor serum potassium and magnesium frequently and replace potassium as needed. Reassess the doses of both drugs if hypokalemia persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Furosemide?
MediHelp rates the interaction as moderate. Fludrocortisone and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents increase urinary potassium loss, so concurrent use can cause significant hypokalemia. Fludrocortisone has strong mineralocorticoid activity, making the effect more pronounced and raising arrhythmia risk.
How serious is the interaction between Fludrocortisone and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium frequently and replace potassium as needed. Reassess the doses of both drugs if hypokalemia persists.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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