Drug interactions
Fludrocortisone + Itraconazole
Severity: Moderate
Fludrocortisone and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase fludrocortisone exposure. This may cause fluid retention, hypertension and hypokalemia.
What this interaction means in plain words
Fludrocortisone and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4-mediated corticosteroid metabolism.
What to do
Monitor blood pressure, edema and serum potassium. Reduce the fludrocortisone dose if mineralocorticoid excess develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Itraconazole?
MediHelp rates the interaction as moderate. Fludrocortisone and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase fludrocortisone exposure. This may cause fluid retention, hypertension and hypokalemia.
How serious is the interaction between Fludrocortisone and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and serum potassium. Reduce the fludrocortisone dose if mineralocorticoid excess develops.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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