Drug interactions
Fludrocortisone + Lornoxicam
Severity: Moderate
Fludrocortisone and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with an NSAID increases the risk of gastrointestinal irritation, ulceration and bleeding. Both drugs can also cause fluid retention and raise blood pressure, which may be relevant given fludrocortisone's mineralocorticoid action.
What this interaction means in plain words
Fludrocortisone and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive gastric mucosal injury (NSAID prostaglandin inhibition plus corticosteroid effects) and additive sodium and fluid retention.
What to do
Use the lowest effective NSAID dose for the shortest time, consider gastroprotection with a proton pump inhibitor, and monitor blood pressure, edema and GI bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Other interactions of Lornoxicam
Frequently asked questions
Can I take Fludrocortisone with Lornoxicam?
MediHelp rates the interaction as moderate. Fludrocortisone and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with an NSAID increases the risk of gastrointestinal irritation, ulceration and bleeding. Both drugs can also cause fluid retention and raise blood pressure, which may be relevant given fludrocortisone's mineralocorticoid action.
How serious is the interaction between Fludrocortisone and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time, consider gastroprotection with a proton pump inhibitor, and monitor blood pressure, edema and GI bleeding signs.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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