Drug interactions
Fludrocortisone + Mefenamic acid
Severity: Moderate
Fludrocortisone and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids taken with an NSAID increase the risk of gastric ulceration and bleeding. Fludrocortisone's fluid retention may also counteract blood pressure control in some patients.
What this interaction means in plain words
Fludrocortisone and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Additive gastric mucosal injury from reduced protective prostaglandins and impaired mucosal healing; NSAID sodium retention adds to mineralocorticoid effects.
What to do
Use the lowest NSAID dose for the shortest time and consider gastroprotection. Monitor blood pressure, edema and GI symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Mefenamic acid?
MediHelp rates the interaction as moderate. Fludrocortisone and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids taken with an NSAID increase the risk of gastric ulceration and bleeding. Fludrocortisone's fluid retention may also counteract blood pressure control in some patients.
How serious is the interaction between Fludrocortisone and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest NSAID dose for the shortest time and consider gastroprotection. Monitor blood pressure, edema and GI symptoms.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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