Drug interactions
Fludrocortisone + Mesterolone
Severity: Minor
Fludrocortisone and Mesterolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both fludrocortisone and androgens such as mesterolone can promote sodium and water retention. Together they may increase the risk of edema, which matters in patients with heart failure, hypertension or renal impairment.
What this interaction means in plain words
Fludrocortisone and Mesterolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Mesterolone belongs to Endocrine.
Why it happens
Additive pharmacodynamic sodium and fluid retention from mineralocorticoid and androgenic effects.
What to do
Monitor body weight, blood pressure and signs of edema, and review the doses if fluid retention develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fludrocortisone
Other interactions of Mesterolone
Frequently asked questions
Can I take Fludrocortisone with Mesterolone?
MediHelp rates the interaction as minor. Fludrocortisone and Mesterolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both fludrocortisone and androgens such as mesterolone can promote sodium and water retention. Together they may increase the risk of edema, which matters in patients with heart failure, hypertension or renal impairment.
How serious is the interaction between Fludrocortisone and Mesterolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor body weight, blood pressure and signs of edema, and review the doses if fluid retention develops.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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