Drug interactions
Fludrocortisone + Moxifloxacin
Severity: Moderate
Fludrocortisone and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids with fluoroquinolones raise the risk of tendon injury, but fludrocortisone is mainly mineralocorticoid and used at low doses, so the tendon risk is probably lower. Fludrocortisone can also cause hypokalemia, which may add to moxifloxacin QT risk.
What this interaction means in plain words
Fludrocortisone and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Possible additive tendon toxicity from corticosteroid effects, plus fludrocortisone-induced potassium loss potentiating QT prolongation.
What to do
Monitor serum potassium and counsel the patient to report tendon pain promptly. Stop moxifloxacin if tendon symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fludrocortisone and Moxifloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Moxifloxacin?
MediHelp rates the interaction as moderate. Fludrocortisone and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids with fluoroquinolones raise the risk of tendon injury, but fludrocortisone is mainly mineralocorticoid and used at low doses, so the tendon risk is probably lower. Fludrocortisone can also cause hypokalemia, which may add to moxifloxacin QT risk.
How serious is the interaction between Fludrocortisone and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and counsel the patient to report tendon pain promptly. Stop moxifloxacin if tendon symptoms occur.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
