Drug interactions
Fludrocortisone + Nabumetone
Severity: Moderate
Fludrocortisone and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with a corticosteroid raises the risk of gastric irritation, ulceration and gastrointestinal bleeding. Fludrocortisone is mainly a mineralocorticoid, so the ulcer risk is likely lower than with glucocorticoids, but fluid retention and edema may be additive.
What this interaction means in plain words
Fludrocortisone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAID-mediated loss of gastric mucosal prostaglandin protection is combined with corticosteroid effects on mucosal integrity, and both promote sodium and fluid retention.
What to do
Use the lowest effective nabumetone dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Monitor blood pressure, edema and signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Nabumetone?
MediHelp rates the interaction as moderate. Fludrocortisone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with a corticosteroid raises the risk of gastric irritation, ulceration and gastrointestinal bleeding. Fludrocortisone is mainly a mineralocorticoid, so the ulcer risk is likely lower than with glucocorticoids, but fluid retention and edema may be additive.
How serious is the interaction between Fludrocortisone and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective nabumetone dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Monitor blood pressure, edema and signs of GI bleeding.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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