Drug interactions
Fludrocortisone + Piroxicam
Severity: Moderate
Fludrocortisone and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids with NSAIDs raise ulcer and GI bleeding risk, though fludrocortisone has mainly mineralocorticoid activity so the ulcer risk is likely lower. Both can also promote fluid retention and raise blood pressure.
What this interaction means in plain words
Fludrocortisone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Piroxicam belongs to Musculoskeletal.
Why it happens
Additive effects on mucosal protection and sodium and fluid retention.
What to do
Monitor blood pressure, edema and GI symptoms, and consider gastroprotection in patients with ulcer risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Piroxicam?
MediHelp rates the interaction as moderate. Fludrocortisone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids with NSAIDs raise ulcer and GI bleeding risk, though fludrocortisone has mainly mineralocorticoid activity so the ulcer risk is likely lower. Both can also promote fluid retention and raise blood pressure.
How serious is the interaction between Fludrocortisone and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and GI symptoms, and consider gastroprotection in patients with ulcer risk factors.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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