Drug interactions
Fludrocortisone + Rosiglitazone
Severity: Minor
Fludrocortisone and Rosiglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has some glucocorticoid activity that can raise blood glucose, which may weaken rosiglitazone's effect. Both drugs can also cause fluid retention, which matters in patients at risk of heart failure.
What this interaction means in plain words
Fludrocortisone and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism of glucose lowering plus additive sodium and fluid retention.
What to do
Monitor blood glucose, weight and signs of edema or heart failure, and adjust therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fludrocortisone
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Fludrocortisone with Rosiglitazone?
MediHelp rates the interaction as minor. Fludrocortisone and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fludrocortisone has some glucocorticoid activity that can raise blood glucose, which may weaken rosiglitazone's effect. Both drugs can also cause fluid retention, which matters in patients at risk of heart failure.
How serious is the interaction between Fludrocortisone and Rosiglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, weight and signs of edema or heart failure, and adjust therapy if needed.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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