Drug interactions
Fludrocortisone + Tacrolimus
Severity: Minor
Fludrocortisone and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can influence potassium and blood pressure: fludrocortisone promotes potassium loss and sodium retention, while tacrolimus can cause hyperkalemia, hypertension and hypomagnesemia. Net effects on electrolytes and blood pressure are variable.
What this interaction means in plain words
Fludrocortisone and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Opposing and additive pharmacodynamic effects on renal electrolyte handling and blood pressure.
What to do
Monitor serum potassium, magnesium, blood pressure and tacrolimus trough levels when starting or changing fludrocortisone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fludrocortisone
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Fludrocortisone with Tacrolimus?
MediHelp rates the interaction as minor. Fludrocortisone and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can influence potassium and blood pressure: fludrocortisone promotes potassium loss and sodium retention, while tacrolimus can cause hyperkalemia, hypertension and hypomagnesemia. Net effects on electrolytes and blood pressure are variable.
How serious is the interaction between Fludrocortisone and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium, blood pressure and tacrolimus trough levels when starting or changing fludrocortisone.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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