Drug interactions
Fluorouracil + Lacosamide
Severity: Minor
Fluorouracil and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluorouracil is not an established CYP2C9 inhibitor, and lacosamide has several clearance pathways. A clinically relevant increase in lacosamide levels is unlikely.
What this interaction means in plain words
Fluorouracil and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluorouracil belongs to Oncology; Lacosamide belongs to Central Nervous System.
Why it happens
Theoretical weak CYP2C9 inhibition; not clinically established.
What to do
No dose change is needed. Monitor for lacosamide adverse effects such as dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Fluorouracil
Frequently asked questions
Can I take Fluorouracil with Lacosamide?
MediHelp rates the interaction as minor. Fluorouracil and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluorouracil is not an established CYP2C9 inhibitor, and lacosamide has several clearance pathways. A clinically relevant increase in lacosamide levels is unlikely.
How serious is the interaction between Fluorouracil and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for lacosamide adverse effects such as dizziness.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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