Drug interactions
Fluoxetine + Fluticasone-vilanterol
Severity: Moderate
Fluoxetine and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can prolong the QT interval, and vilanterol as a long-acting beta2-agonist can influence heart rate and repolarization, especially when potassium is low. The combination may modestly increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Fluoxetine and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization via QT prolongation and beta2-agonist-related hypokalemia and tachycardia.
What to do
Obtain an ECG and check potassium in patients with cardiac disease or other QT-prolonging drugs, and correct electrolyte abnormalities. Avoid exceeding recommended vilanterol doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluoxetine and Fluticasone-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluticasone-vilanterol
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Fluoxetine and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can prolong the QT interval, and vilanterol as a long-acting beta2-agonist can influence heart rate and repolarization, especially when potassium is low. The combination may modestly increase arrhythmia risk in susceptible patients.
How serious is the interaction between Fluoxetine and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check potassium in patients with cardiac disease or other QT-prolonging drugs, and correct electrolyte abnormalities. Avoid exceeding recommended vilanterol doses.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
