Drug interactions
Fluoxetine + Gabapentin enacarbil
Severity: Moderate
Fluoxetine and Gabapentin enacarbil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can cause sedation and dizziness, and use with other CNS depressants may increase the risk of respiratory depression. The effect is usually modest with an SSRI alone but can matter in older or frail patients.
What this interaction means in plain words
Fluoxetine and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Start with low gabapentin enacarbil doses and titrate gradually. Monitor for excessive sedation, impaired coordination and breathing difficulty, especially in elderly patients or those with lung disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Fluoxetine with Gabapentin enacarbil?
MediHelp rates the interaction as moderate. Fluoxetine and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can cause sedation and dizziness, and use with other CNS depressants may increase the risk of respiratory depression. The effect is usually modest with an SSRI alone but can matter in older or frail patients.
How serious is the interaction between Fluoxetine and Gabapentin enacarbil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low gabapentin enacarbil doses and titrate gradually. Monitor for excessive sedation, impaired coordination and breathing difficulty, especially in elderly patients or those with lung disease.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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