Drug interactions
Fluoxetine + Isavuconazonium
Severity: Minor
Fluoxetine and Isavuconazonium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate, and fluoxetine and norfluoxetine are weak inhibitors of CYP3A4. Any increase in isavuconazole exposure is expected to be small and of limited clinical importance.
What this interaction means in plain words
Fluoxetine and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Isavuconazonium belongs to Anti Fungals.
Why it happens
Weak inhibition of CYP3A4 by fluoxetine and norfluoxetine may slightly reduce isavuconazole clearance.
What to do
No dose adjustment is usually needed; monitor for isavuconazole adverse effects such as liver enzyme elevations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Fluoxetine with Isavuconazonium?
MediHelp rates the interaction as minor. Fluoxetine and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a CYP3A4 substrate, and fluoxetine and norfluoxetine are weak inhibitors of CYP3A4. Any increase in isavuconazole exposure is expected to be small and of limited clinical importance.
How serious is the interaction between Fluoxetine and Isavuconazonium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for isavuconazole adverse effects such as liver enzyme elevations.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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