Drug interactions
Fluoxetine + Lemborexant
Severity: Moderate
Fluoxetine and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine may raise lemborexant levels through weak CYP3A4 inhibition, and both drugs can cause sedation. This may increase somnolence and next-day impairment.
What this interaction means in plain words
Fluoxetine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by fluoxetine plus additive CNS depression.
What to do
Limit lemborexant to the lower recommended dose when used with weak CYP3A4 inhibitors. Counsel the patient about daytime drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Fluoxetine with Lemborexant?
MediHelp rates the interaction as moderate. Fluoxetine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine may raise lemborexant levels through weak CYP3A4 inhibition, and both drugs can cause sedation. This may increase somnolence and next-day impairment.
How serious is the interaction between Fluoxetine and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the lower recommended dose when used with weak CYP3A4 inhibitors. Counsel the patient about daytime drowsiness and driving.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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