Drug interactions
Fluoxetine + Levofloxacin
Severity: Moderate
Fluoxetine and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine has been linked to QT prolongation in some patients, and levofloxacin adds further risk. The combination may modestly increase the likelihood of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Fluoxetine and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through potassium channel effects.
What to do
Check electrolytes and obtain an ECG in patients with cardiac disease or other QT-prolonging drugs. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Levofloxacin?
MediHelp rates the interaction as moderate. Fluoxetine and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine has been linked to QT prolongation in some patients, and levofloxacin adds further risk. The combination may modestly increase the likelihood of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Fluoxetine and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check electrolytes and obtain an ECG in patients with cardiac disease or other QT-prolonging drugs. Monitor for palpitations or syncope.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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