Drug interactions
Fluoxetine + Linagliptin-metformin
Severity: Minor
Fluoxetine and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine may enhance glucose-lowering and has been associated with hypoglycemia in patients on antidiabetic drugs. The effect is variable and usually mild.
What this interaction means in plain words
Fluoxetine and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Linagliptin-metformin belongs to Endocrine.
Why it happens
Possible improvement of insulin sensitivity via serotonergic effects; mechanism not firmly established.
What to do
Monitor blood glucose when starting or stopping fluoxetine and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Linagliptin-metformin?
MediHelp rates the interaction as minor. Fluoxetine and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine may enhance glucose-lowering and has been associated with hypoglycemia in patients on antidiabetic drugs. The effect is variable and usually mild.
How serious is the interaction between Fluoxetine and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fluoxetine and adjust antidiabetic therapy if needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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