Drug interactions
Fluoxetine + Naratriptan
Severity: Moderate
Fluoxetine and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with a triptan carries a reported risk of serotonin syndrome, with agitation, tremor, hyperthermia and neuromuscular hyperactivity. The incidence appears low, but the reaction can be serious.
What this interaction means in plain words
Fluoxetine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects through SSRI reuptake inhibition and triptan 5-HT1B/1D agonism.
What to do
Counsel the patient to report symptoms of serotonin toxicity and monitor especially at initiation or dose increases; stop one agent if signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Fluoxetine with Naratriptan?
MediHelp rates the interaction as moderate. Fluoxetine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with a triptan carries a reported risk of serotonin syndrome, with agitation, tremor, hyperthermia and neuromuscular hyperactivity. The incidence appears low, but the reaction can be serious.
How serious is the interaction between Fluoxetine and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report symptoms of serotonin toxicity and monitor especially at initiation or dose increases; stop one agent if signs appear.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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