Drug interactions
Fluoxetine + Oxymorphone
Severity: Minor
Fluoxetine and Oxymorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine strongly inhibits CYP2D6, but oxymorphone is metabolised mainly by glucuronidation rather than CYP2D6, so a meaningful rise in exposure is not expected. Any clinical effect is likely minor.
What this interaction means in plain words
Fluoxetine and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
CYP2D6 inhibition has little relevance because oxymorphone is cleared mainly by UGT2B7 glucuronidation.
What to do
No dose adjustment is usually needed. Monitor for opioid effects when starting or stopping fluoxetine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluoxetine and Oxymorphone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Oxymorphone?
MediHelp rates the interaction as minor. Fluoxetine and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine strongly inhibits CYP2D6, but oxymorphone is metabolised mainly by glucuronidation rather than CYP2D6, so a meaningful rise in exposure is not expected. Any clinical effect is likely minor.
How serious is the interaction between Fluoxetine and Oxymorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for opioid effects when starting or stopping fluoxetine.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
