Drug interactions
Fluoxetine + Quetiapine
Severity: Moderate
Fluoxetine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, and the combination may add to arrhythmia risk, particularly with overdose, electrolyte disturbance or cardiac disease. Fluoxetine may also modestly affect quetiapine exposure.
What this interaction means in plain words
Fluoxetine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Check a baseline ECG and electrolytes in patients with risk factors and monitor periodically. Avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Fluoxetine with Quetiapine?
MediHelp rates the interaction as moderate. Fluoxetine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, and the combination may add to arrhythmia risk, particularly with overdose, electrolyte disturbance or cardiac disease. Fluoxetine may also modestly affect quetiapine exposure.
How serious is the interaction between Fluoxetine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes in patients with risk factors and monitor periodically. Avoid adding other QT-prolonging drugs.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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