Drug interactions
Fluoxetine + Quizartinib
Severity: Major
Fluoxetine and Quizartinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib markedly prolongs the QT interval and can cause torsades de pointes, and fluoxetine adds further QT effect. Fluoxetine is also a CYP3A inhibitor of limited strength, which may modestly raise quizartinib exposure.
What this interaction means in plain words
Fluoxetine and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluoxetine belongs to Central Nervous System; Quizartinib belongs to Oncology.
Why it happens
Additive QT prolongation; fluoxetine may also weakly inhibit CYP3A-mediated quizartinib metabolism.
What to do
Avoid the combination where possible and consider an alternative antidepressant. If combined, monitor ECG and electrolytes closely and follow the quizartinib labeling for dose reduction with CYP3A inhibitors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Fluoxetine with Quizartinib?
MediHelp rates the interaction as major. Fluoxetine and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib markedly prolongs the QT interval and can cause torsades de pointes, and fluoxetine adds further QT effect. Fluoxetine is also a CYP3A inhibitor of limited strength, which may modestly raise quizartinib exposure.
How serious is the interaction between Fluoxetine and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider an alternative antidepressant. If combined, monitor ECG and electrolytes closely and follow the quizartinib labeling for dose reduction with CYP3A inhibitors.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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