Drug interactions
Fluoxetine + Sparsentan
Severity: Minor
Fluoxetine and Sparsentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan induces CYP2C9, which contributes to fluoxetine metabolism, so fluoxetine exposure may fall modestly. This could slightly reduce antidepressant effect, though fluoxetine's long-lived metabolite buffers the change.
What this interaction means in plain words
Fluoxetine and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Sparsentan belongs to Genitourinary.
Why it happens
Induction of CYP2C9 by sparsentan increasing fluoxetine clearance.
What to do
Monitor depressive symptoms after sparsentan is started and adjust the fluoxetine dose if response declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Fluoxetine with Sparsentan?
MediHelp rates the interaction as minor. Fluoxetine and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sparsentan induces CYP2C9, which contributes to fluoxetine metabolism, so fluoxetine exposure may fall modestly. This could slightly reduce antidepressant effect, though fluoxetine's long-lived metabolite buffers the change.
How serious is the interaction between Fluoxetine and Sparsentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor depressive symptoms after sparsentan is started and adjust the fluoxetine dose if response declines.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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