Drug interactions
Fluoxetine + Sulindac
Severity: Moderate
Fluoxetine and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs combined with NSAIDs increase the risk of upper gastrointestinal bleeding beyond that of either drug alone. The risk is greater in older patients and those with prior ulcers or anticoagulant use.
What this interaction means in plain words
Fluoxetine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Sulindac belongs to Musculoskeletal.
Why it happens
SSRIs deplete platelet serotonin and impair platelet aggregation, while NSAIDs inhibit platelet function and injure gastric mucosa, giving additive bleeding risk.
What to do
Add a proton pump inhibitor in patients at high GI risk and monitor for melena, hematemesis or anemia. Consider a non-NSAID analgesic where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluoxetine and Sulindac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Sulindac?
MediHelp rates the interaction as moderate. Fluoxetine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs combined with NSAIDs increase the risk of upper gastrointestinal bleeding beyond that of either drug alone. The risk is greater in older patients and those with prior ulcers or anticoagulant use.
How serious is the interaction between Fluoxetine and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a proton pump inhibitor in patients at high GI risk and monitor for melena, hematemesis or anemia. Consider a non-NSAID analgesic where feasible.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
