Drug interactions
Fluoxetine + Tolfenamic acid
Severity: Moderate
Fluoxetine and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with an NSAID increases the risk of gastrointestinal bleeding compared with either drug alone. Risk is higher in older adults and those with prior ulcers or anticoagulant use.
What this interaction means in plain words
Fluoxetine and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
SSRI-related platelet serotonin depletion impairs aggregation, while the NSAID inhibits platelets and injures gastric mucosa.
What to do
Avoid the combination in high-risk patients, or add a proton pump inhibitor and use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Fluoxetine with Tolfenamic acid?
MediHelp rates the interaction as moderate. Fluoxetine and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with an NSAID increases the risk of gastrointestinal bleeding compared with either drug alone. Risk is higher in older adults and those with prior ulcers or anticoagulant use.
How serious is the interaction between Fluoxetine and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in high-risk patients, or add a proton pump inhibitor and use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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