Drug interactions
Fluoxetine + Umeclidinium-vilanterol
Severity: Moderate
Fluoxetine and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can prolong the QT interval, and beta2-agonists such as vilanterol can add to cardiovascular effects including QTc prolongation and tachycardia. The risk is higher with high doses, hypokalemia or underlying cardiac disease.
What this interaction means in plain words
Fluoxetine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive pharmacodynamic QT prolongation and beta2-mediated cardiovascular stimulation, with possible hypokalemia from the beta-agonist.
What to do
Check baseline ECG and electrolytes in patients with QT risk factors. Keep the inhaled dose at the labeled level and correct low potassium or magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Fluoxetine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can prolong the QT interval, and beta2-agonists such as vilanterol can add to cardiovascular effects including QTc prolongation and tachycardia. The risk is higher with high doses, hypokalemia or underlying cardiac disease.
How serious is the interaction between Fluoxetine and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with QT risk factors. Keep the inhaled dose at the labeled level and correct low potassium or magnesium.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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