Drug interactions
Fluoxetine + Vardenafil
Severity: Moderate
Fluoxetine and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil has a small QT-prolonging effect and fluoxetine can prolong QT at higher exposures. Combined use might slightly raise arrhythmia risk, especially with other risk factors.
What this interaction means in plain words
Fluoxetine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Additive QT interval prolongation; fluoxetine also weakly inhibits CYP3A4.
What to do
Check for other QT risk factors such as electrolyte disturbance, and obtain an ECG in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Vardenafil?
MediHelp rates the interaction as moderate. Fluoxetine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vardenafil has a small QT-prolonging effect and fluoxetine can prolong QT at higher exposures. Combined use might slightly raise arrhythmia risk, especially with other risk factors.
How serious is the interaction between Fluoxetine and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check for other QT risk factors such as electrolyte disturbance, and obtain an ECG in high-risk patients.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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