Drug interactions
Fluoxetine + Voclosporin
Severity: Moderate
Fluoxetine and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin carries a QT prolongation warning at supratherapeutic exposure, and fluoxetine also prolongs QT, so the effects may add. Fluoxetine is a weak CYP3A4 inhibitor and may modestly raise voclosporin levels.
What this interaction means in plain words
Fluoxetine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QT prolongation, with possible weak CYP3A4 inhibition raising voclosporin exposure.
What to do
Monitor ECG and electrolytes if risk factors for QT prolongation are present. Monitor renal function and blood pressure as per voclosporin labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Fluoxetine with Voclosporin?
MediHelp rates the interaction as moderate. Fluoxetine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin carries a QT prolongation warning at supratherapeutic exposure, and fluoxetine also prolongs QT, so the effects may add. Fluoxetine is a weak CYP3A4 inhibitor and may modestly raise voclosporin levels.
How serious is the interaction between Fluoxetine and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes if risk factors for QT prolongation are present. Monitor renal function and blood pressure as per voclosporin labeling.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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