Drug interactions
Fluoxymesterone + Glipizide
Severity: Moderate
Fluoxymesterone and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens such as fluoxymesterone can improve insulin sensitivity and lower glucose, which may enhance the effect of glipizide and increase hypoglycemia risk. The effect is generally modest but may matter in patients with tight control.
What this interaction means in plain words
Fluoxymesterone and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anabolic androgens may increase insulin sensitivity and reduce blood glucose, adding to sulfonylurea effect.
What to do
Monitor blood glucose when starting or stopping fluoxymesterone and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Fluoxymesterone with Glipizide?
MediHelp rates the interaction as moderate. Fluoxymesterone and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens such as fluoxymesterone can improve insulin sensitivity and lower glucose, which may enhance the effect of glipizide and increase hypoglycemia risk. The effect is generally modest but may matter in patients with tight control.
How serious is the interaction between Fluoxymesterone and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fluoxymesterone and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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