Drug interactions
Fluphenazine + Fosinopril
Severity: Minor
Fluphenazine and Fosinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine can cause orthostatic hypotension, though less than low-potency phenothiazines. With fosinopril, additive blood pressure lowering may occur.
What this interaction means in plain words
Fluphenazine and Fosinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluphenazine belongs to Central Nervous System; Fosinopril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade and ACE inhibition.
What to do
Check blood pressure and ask about dizziness after starting or changing doses; adjust the antihypertensive if hypotension is symptomatic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Fosinopril?
MediHelp rates the interaction as minor. Fluphenazine and Fosinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluphenazine can cause orthostatic hypotension, though less than low-potency phenothiazines. With fosinopril, additive blood pressure lowering may occur.
How serious is the interaction between Fluphenazine and Fosinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure and ask about dizziness after starting or changing doses; adjust the antihypertensive if hypotension is symptomatic.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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