Drug interactions
Fluphenazine + Givinostat
Severity: Moderate
Fluphenazine and Givinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, and fluphenazine adds to this effect, raising the risk of serious ventricular arrhythmia. The risk is higher with bradycardia, electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Fluphenazine and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain ECGs at initiation and during concomitant use, and correct electrolyte disturbances. Withhold givinostat if QTc exceeds 500 ms or rises more than 60 ms above baseline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Fluphenazine with Givinostat?
MediHelp rates the interaction as moderate. Fluphenazine and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QT interval, and fluphenazine adds to this effect, raising the risk of serious ventricular arrhythmia. The risk is higher with bradycardia, electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Fluphenazine and Givinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs at initiation and during concomitant use, and correct electrolyte disturbances. Withhold givinostat if QTc exceeds 500 ms or rises more than 60 ms above baseline.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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