Drug interactions
Fluphenazine + Glipizide-metformin
Severity: Moderate
Fluphenazine and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics such as fluphenazine may worsen glycemic control and reduce the effectiveness of antidiabetic drugs. Glucose may rise after initiation and fall when the antipsychotic is withdrawn.
What this interaction means in plain words
Fluphenazine and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Glipizide-metformin belongs to Endocrine.
Why it happens
Antipsychotics can cause insulin resistance and reduce insulin secretion, opposing the effect of glipizide and metformin.
What to do
Monitor blood glucose and HbA1c after fluphenazine is started or changed, and adjust antidiabetic doses as needed. Watch for hypoglycemia when the antipsychotic is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Glipizide-metformin?
MediHelp rates the interaction as moderate. Fluphenazine and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazine antipsychotics such as fluphenazine may worsen glycemic control and reduce the effectiveness of antidiabetic drugs. Glucose may rise after initiation and fall when the antipsychotic is withdrawn.
How serious is the interaction between Fluphenazine and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after fluphenazine is started or changed, and adjust antidiabetic doses as needed. Watch for hypoglycemia when the antipsychotic is stopped.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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