Drug interactions
Fluphenazine + Glyburide-metformin
Severity: Moderate
Fluphenazine and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as fluphenazine can raise blood glucose and reduce the effectiveness of antidiabetic drugs. Glycemic control may worsen, and hypoglycemia may occur when the antipsychotic is withdrawn.
What this interaction means in plain words
Fluphenazine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Glyburide-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through impaired insulin secretion and increased insulin resistance.
What to do
Monitor blood glucose and HbA1c after starting fluphenazine and adjust antidiabetic therapy as needed. Watch for hypoglycemia if fluphenazine is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Glyburide-metformin?
MediHelp rates the interaction as moderate. Fluphenazine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines such as fluphenazine can raise blood glucose and reduce the effectiveness of antidiabetic drugs. Glycemic control may worsen, and hypoglycemia may occur when the antipsychotic is withdrawn.
How serious is the interaction between Fluphenazine and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting fluphenazine and adjust antidiabetic therapy as needed. Watch for hypoglycemia if fluphenazine is discontinued.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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