Drug interactions
Fluphenazine + Isoflurane
Severity: Moderate
Fluphenazine and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both isoflurane and fluphenazine can prolong the QT interval, and phenothiazines add to hypotension and CNS depression during anesthesia. This raises the risk of arrhythmia perioperatively.
What this interaction means in plain words
Fluphenazine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Isoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation, together with additive CNS depression and vasodilatory effects.
What to do
Tell the anesthesia team about fluphenazine use, review the baseline ECG and electrolytes, and monitor ECG and blood pressure during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Isoflurane
Frequently asked questions
Can I take Fluphenazine with Isoflurane?
MediHelp rates the interaction as moderate. Fluphenazine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both isoflurane and fluphenazine can prolong the QT interval, and phenothiazines add to hypotension and CNS depression during anesthesia. This raises the risk of arrhythmia perioperatively.
How serious is the interaction between Fluphenazine and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about fluphenazine use, review the baseline ECG and electrolytes, and monitor ECG and blood pressure during anesthesia.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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