Drug interactions
Fluphenazine + Lofexidine
Severity: Major
Fluphenazine and Lofexidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is an alpha-2 agonist that causes sedation, hypotension and bradycardia, and it also prolongs the QT interval. Fluphenazine adds sedation and hypotension and also prolongs the QT interval, so the combination can increase these risks.
What this interaction means in plain words
Fluphenazine and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluphenazine belongs to Central Nervous System; Lofexidine belongs to Central Nervous System.
Why it happens
Additive CNS depression, hypotension and QT prolongation.
What to do
Monitor blood pressure, heart rate and ECG, and correct potassium and magnesium abnormalities. Avoid the combination in patients with congenital long QT or bradycardia, or reduce the doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Fluphenazine with Lofexidine?
MediHelp rates the interaction as major. Fluphenazine and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lofexidine is an alpha-2 agonist that causes sedation, hypotension and bradycardia, and it also prolongs the QT interval. Fluphenazine adds sedation and hypotension and also prolongs the QT interval, so the combination can increase these risks.
How serious is the interaction between Fluphenazine and Lofexidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG, and correct potassium and magnesium abnormalities. Avoid the combination in patients with congenital long QT or bradycardia, or reduce the doses.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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