Drug interactions
Fluphenazine + Lorazepam
Severity: Moderate
Fluphenazine and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine is a phenothiazine antipsychotic, and with lorazepam it produces additive sedation. Hypotension and respiratory depression may occur, particularly with parenteral use or in vulnerable patients.
What this interaction means in plain words
Fluphenazine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension from GABA-A potentiation plus dopamine, histamine and alpha-adrenergic blockade.
What to do
Monitor sedation, blood pressure and respiratory status, especially after injections or dose changes. Reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Lorazepam?
MediHelp rates the interaction as moderate. Fluphenazine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine is a phenothiazine antipsychotic, and with lorazepam it produces additive sedation. Hypotension and respiratory depression may occur, particularly with parenteral use or in vulnerable patients.
How serious is the interaction between Fluphenazine and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and respiratory status, especially after injections or dose changes. Reduce doses if excessive sedation occurs.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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