Drug interactions
Fluphenazine + Metformin-pioglitazone
Severity: Minor
Fluphenazine and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics can cause hyperglycemia and impair glucose tolerance, though fluphenazine has less metabolic effect than many atypical agents. This may reduce control of diabetes.
What this interaction means in plain words
Fluphenazine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluphenazine belongs to Central Nervous System; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Antipsychotic-related insulin resistance and reduced insulin secretion oppose antidiabetic effects.
What to do
Monitor blood glucose and HbA1c after starting fluphenazine and adjust antidiabetic therapy accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Fluphenazine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazine antipsychotics can cause hyperglycemia and impair glucose tolerance, though fluphenazine has less metabolic effect than many atypical agents. This may reduce control of diabetes.
How serious is the interaction between Fluphenazine and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting fluphenazine and adjust antidiabetic therapy accordingly.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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