Drug interactions
Fluphenazine + Metformin-repaglinide
Severity: Moderate
Fluphenazine and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics can impair glucose tolerance and raise blood glucose, potentially reducing the effect of antidiabetic drugs. Glucose may fall again when the antipsychotic is withdrawn.
What this interaction means in plain words
Fluphenazine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Metformin-repaglinide belongs to Endocrine.
Why it happens
Antipsychotic-induced insulin resistance and impaired insulin secretion opposing antidiabetic action.
What to do
Monitor blood glucose when fluphenazine is started, changed, or stopped and adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Fluphenazine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazine antipsychotics can impair glucose tolerance and raise blood glucose, potentially reducing the effect of antidiabetic drugs. Glucose may fall again when the antipsychotic is withdrawn.
How serious is the interaction between Fluphenazine and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fluphenazine is started, changed, or stopped and adjust antidiabetic doses accordingly.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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