Drug interactions
Fluphenazine + Paroxetine
Severity: Moderate
Fluphenazine and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine inhibits CYP2D6, which metabolizes fluphenazine, so fluphenazine levels may rise and increase extrapyramidal symptoms, sedation, and QT effects. Both drugs may also contribute to QTc prolongation.
What this interaction means in plain words
Fluphenazine and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Paroxetine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by paroxetine decreasing fluphenazine clearance, with additive QTc effects.
What to do
Monitor for extrapyramidal symptoms and consider a lower fluphenazine dose. Check ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Paroxetine?
MediHelp rates the interaction as moderate. Fluphenazine and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine inhibits CYP2D6, which metabolizes fluphenazine, so fluphenazine levels may rise and increase extrapyramidal symptoms, sedation, and QT effects. Both drugs may also contribute to QTc prolongation.
How serious is the interaction between Fluphenazine and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and consider a lower fluphenazine dose. Check ECG in patients with cardiac risk factors.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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