Drug interactions
Fluphenazine + Phenelzine
Severity: Moderate
Fluphenazine and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine with an MAOI may cause additive hypotension, sedation and extrapyramidal effects, and rarely neuroleptic malignant syndrome or serotonin syndrome. Phenothiazines may also enhance MAOI-related hypotension.
What this interaction means in plain words
Fluphenazine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects: dopamine D2 blockade and alpha-adrenergic blockade combined with the monoamine effects and hypotensive action of MAO inhibition.
What to do
Monitor blood pressure and for rigidity, fever and altered mental status, especially after dose changes. Stop one agent if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Phenelzine?
MediHelp rates the interaction as moderate. Fluphenazine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine with an MAOI may cause additive hypotension, sedation and extrapyramidal effects, and rarely neuroleptic malignant syndrome or serotonin syndrome. Phenothiazines may also enhance MAOI-related hypotension.
How serious is the interaction between Fluphenazine and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for rigidity, fever and altered mental status, especially after dose changes. Stop one agent if toxicity is suspected.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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